the molecular investigation of celiac disease
نویسندگان
چکیده
celiac disease (cd) is an immune-mediated disorder resulting in nutrient malabsorption now thought to have a prevalence of 1:100 in the iranian population.symptoms of cd are included diarrhea, abdominal pain, steatorrhea, bloating, cramps, flatulence, weight loss, weakness and short stature. in addition to presenting symptoms, patients are also at increased risk of metabolic bone disease, lymphoma (enteropathy-associated with t-cell) and other malignancies in different parts of the body such as gastric, esophageal, bladder, breast and brain. there appears to be a strong genetic component to this disease. in this short review we provided the historical, clinical and genetic aspects of this disease and highlight numerous findings from recent molecular immunology studies.
منابع مشابه
Molecular basis of celiac disease.
Celiac disease (CD) is an intestinal disorder with multifactorial etiology. HLA and non-HLA genes together with gluten and possibly additional environmental factors are involved in disease development. Evidence suggests that CD4(+) T cells are central in controlling an immune response to gluten that causes the immunopathology, but the actual mechanisms responsible for the tissue damage are as y...
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چکیده ندارد.
Refractory Celiac Disease
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An Overview of Immunogenetic in Celiac Disease
Introduction: Celiac disease is an autoimmune disease caused by persistent intolerance to gluten, which is causedin people who are genetically predisposed. The disease presents with atrophy of the small intestinal mucosa and gastrointestinal and extra-gastrointestinal manifestations.Environmental factors like gluten and genetic factors such as HLA and non-HLA genes are involved in causing the d...
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عنوان ژورنال:
journal of paramedical sciencesجلد ۴، شماره ۱، صفحات ۰-۰
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